Lithium has a narrow therapeutic range. A client who develops vomiting, diarrhea, poor intake, sodium depletion, or reduced kidney function can accumulate lithium even without a dose change. NSAIDs can further increase lithium concentrations by reducing its renal clearance.
Compare patterns
A familiar fine tremor may be a chronic effect. A new coarse tremor, confusion, slurred speech, unsteady gait, or muscle twitching is a concerning change.
Follow the trend
Interpret the lithium concentration together with sodium, creatinine, intake and output, vital signs, and neurologic status.
Review the timing of the blood draw relative to the last dose when interpreting a measured lithium level. Do not dismiss symptomatic deterioration because a prior value was within range.
